Basic information

Title	Activase® (alteplase) for acute ischemic stroke treatment
Description	Acute ischemic stroke indication: activase is indicated for the management of acute ischemic stroke in adults for improving neurological recovery and reducing the incidence of disability. treatment should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography (ct) scan or other diagnostic imaging method sensitive for the presence of hemorrhage (see contraindications in the full prescribing information). acute massive pulmonary embolism indication: activase is indicated in the management of acute massive pulmonary embolism (ampe) in adults: (1) for the lysis of acute pulmonary emboli, defined as obstruction of blood flow to a lobe or multiple segments of the lungs; (2) for the lysis of pulmonary emboli accompanied by unstable hemodynamics, eg, failure to maintain blood pressure without supportive measures. the diagnosis should be confirmed by objective means, such as pulmonary angiography or noninvasive procedures such as lung scanning. acute mycocardial infarction indication: activase (alteplase) is indicated for use in the management of acute myocardial infarction in adults for the improvement of ventricular function following ami, the reduction of the incidence of congestive heart failure, and the reduction of mortality associated with ami. treatment should be initiated as soon as possible after the onset of ami symptoms. important safety information: contraindications acute ischemic stroke (ais): treatment should only be initiated within 3 hours after the onset of stroke symptoms, and after exclusion of intracranial hemorrhage by a cranial computerized tomography (ct) scan or other diagnostic imaging method sensitive for the presence of hemorrhage [see contraindications in the full prescribing information]. activase therapy in patients with ais is contraindicated in certain situations (eg, suspicion of subarachnoid hemorrhage on pretreatment evaluation), recent (within 3 months) intracranial or intraspinal surgery, history of intracranial hemorrhage, uncontrolled hypertension at time of treatment, active internal bleeding, known bleeding diathesis (eg, current use of oral anticoagulants, administration of heparin within 48 hours of onset of stroke, platelet count <100,000/mm3) [see contraindications in the full prescribing information]. pulmonary embolism (pe): activase therapy in patients with pe is contraindicated in certain situations (eg, active internal bleeding, history of cerebrovascular accident, recent intracranial or intraspinal surgery or trauma, severe uncontrolled hypertension) [see contraindications in the full prescribing information]. acute myococardial infarction (ami): activase therapy in patients with acute myocardial infarction (ami) is contraindicated in certain situations because of an increased risk of bleeding (e.g. active internal bleeding, history of cerebrovascular accident, recent intracranial or intraspinal surgery or trauma, severe uncontrolled hypertension) [see contraindications in the full prescribing information]. warnings the risks of activase therapy for all approved indications may be increased and should be weighed against the anticipated benefits in certain conditions [see warnings in the full prescribing information]. cholesterol embolism has been reported rarely in patients treated with all types of thrombolytic agents; the true incidence is unknown. acute ischemic stroke (ais): patients with severe neurological deficit (eg, nihss >22) at presentation. there is an increased risk of intracranial hemorrhage in these patients. patients with major early infarct signs on a computerized cranial tomography (ct) scan (eg, substantial edema, mass effect, or midline shift). treatment of patients with minor neurological deficit or with rapidly improving symptoms is not recommended [see warnings in the full prescribing information]. pulmonary embolism (pe): treatment of pe with activase has not been shown to constitute adequate clinical treatment of underlying deep vein thrombosis. the possible risk of reembolization due to the lysis of underlying deep venous thrombi should be considered. acute myococardial infarction (ami): coronary thrombolysis may result in arrhythmias associated with reperfusion. it is recommended that antiarrhythmic therapy for bradycardia and/or ventricular irritability be available when infusions of activase are administered. precautions (ais) orolingual angioedema has been observed in postmarketing experience in patients treated with activase for ais. patients should be monitored during and for several hours after infusion for signs of orolingual angioedema. adverse reactions the most common complication during activase therapy is bleeding. should serious bleeding in a critical location (intracranial, gastrointestinal, retroperitoneal, pericardial) occur, activase therapy should be discontinued immediately, along with any concomitant therapy with heparin. death and permanent disability are not uncommonly reported in patients who have experienced stroke (including intracranial bleeding) and other serious bleeding episodes. please see www.activase.com for full prescribing information for additional important safety information. activase® (alteplase) is the only fda-approved drug for the treatment of acute ischemic stroke.
Analytics ID	UA-6467920
Adsense ID	/
Ip address	72.34.128.168

Traffic

Each day, activase.com generates 44,535 pageviews from 8,907 visitors. The website receives an average of 276,117 visits and 1,380,585 pageviews per month. It is given a rating of C, due to its good performance.

	Per day	Per week	Per month	Per year
Visitors	8,907	62,349	276,117	3,251,055
Pageviews	44,535	311,745	1,380,585	16,255,275

SEO potential

Activase.com has a Google Pagerank of 4 out of 10 and an Alexa Rank of 76,815. Although being more and more depreciated as a website quality indicator, a higher PageRank still indicates in most cases the popularity of a website. Sites with high Alexa Rank have high amounts of visitors, indicating that they get good search engine rankings.

The domain name was created 25 years ago (year: 1999, month: 04, day: 23) and has a length of 8 characters. Search engines algorithm gives more credibility and authority to websites whose domain name has been registered for a long time and is still in use (but not parked).

It is given a rating of C, due to its good performance.

Pagerank	4/10
Alexa	#76,815
Age	25 years, 6 months and 13 days
Index	View pages indexed in : [Google] [Yahoo] [Bing]

Earnings

Activase.com earns $27 USD a day in advertising revenue. Income from CPC banner ads is $9,855 USD per year. Yearly income from CPM banner ads is $1,626 USD. If the website was up for sale, it could be sold for $73,145 USD. It is given a rating of D, due to its low performance.

	Per day	Per week	Per month	Per year
CPC	27	189	837	9,855
CPM	4	31	138	1,626

Server information

Activase.com resolves to the IP address 72.34.128.168, which is located in San Jose, United States. The amount of bandwidth used by Activase is 3.733 GB per day. Thus, we estimates that activase.com uses a total of 1 server(s), with a cost of $40 USD per month.

Hosting Analysis

Amount of Servers	1
Servers Cost /month	40
Website Bandwidth /day	3.733 GB

Server location

Latitude	37.3394
Longitude	-121.895
City	San Jose
Country	United States

Activase server location : San Jose, United States (37.3394,-121.895)

Domains on same IP (72.34.128.168)

No.	Domain Name	Visitors
1.	activase.com (Activase)	8,907
2.	activase.us (Activase)	0